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Research delves into the role of tau protein in development of Alzheimer's
Thursday, 09 June 2011 09:01

Scientists at UC Santa Barbara recently made an important finding that could have implications for the development of future treatments for Alzheimer's disease. They published a paper in the Journal of Biological Chemistry, revealing what takes place in the brain cells of those with the neurodegenerative disorder.

Lead author Stuart Feinstein explained that in patients with dementia, brain cells needed for proper cognitive function may no longer be working properly. Some nerve cells may die, leading to the loss of neuronal capacity.

The team studied the protein called tau, which is located in the axons that connect neurons to their communicative targets. This component, which normally stabilizes the cellular cytoskeleton, may have a darker role in that it helps a compound called amyloid beta bring about nerve cell death.

The researchers are currently studying the mechanism behind tau's role in the development of Alzheimer's disease.

"That would provide clues for drug companies. They would have a more precise target to work on," Feinstein said. "The more precisely they understand the biochemistry of the target, the better attack a pharmaceutical company can make on a problem."
 

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